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br Introduction Activation of the lipid sensing receptor
2021-12-10
Introduction Activation of the lipid sensing receptor, GPR55, by lysophosphatidyl inositol (LPI) has been well documented, and implicated in endocannabinoid signaling [1]. Intracellular events resulting from GPR55 activation include; enhanced β-arrestin activity, calcium mobilization and ERK1/2 p
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The effect of the selected compounds on
2021-12-10
The effect of the selected compounds on NF-kB transrepression was assessed using the well-studied HeLa B2 cell line that expresses endogenous GR and NF-kB family members and responds properly to glucocorticoids and pro-inflammatory cytokines (such as TNF). Our data revealed that the two hit compound
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During the course of the development of aminothiazole derive
2021-12-10
During the course of the development of aminothiazole-derived small molecule GSMs, SGSM-36 (Fig. 1A) was discovered and exhibited good activity for suppressing the production of Aβ42 (Aβ42 IC50=63nM) (Rynearson et al., 2016; Wagner et al., 2014). In addition, SGSM-36 exhibited improved physicochemic
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To improve the preferential GalR binding we synthesized M wh
2021-12-10
To improve the preferential GalR2 binding, we synthesized M1152 where the N-terminal Gly residue was deleted, in analogy with previously designed M871 (Sollenberg et al., 2006). In addition to the poor affinity of M871 for GalR1, a recent study showed that it also hardly recognized by GalR3 (Sollenb
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br Results and discussion br Conclusion
2021-12-10
Results and discussion Conclusion In the continued SAR study of our previous heterocycle scaffolds represented by kappa opioid receptor 2, we focused especially on improving their drug-like physicochemical properties directed by lipophilicity, LE and LLE. After explored several heterocyclic s
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br Methods and materials br Results br
2021-12-10
Methods and materials Results Discussion In this study we demonstrate that CF epithelial Etoricoxib exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible for t
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We thus asked whether enhanced AEA levels in the
2021-12-10
We thus asked whether enhanced AEA levels in the Mefloquine hydrochloride reduce the level of age-related inflammatory changes and slow down brain ageing. To answer this question we compared the morphology of microglia and level of pro-inflammatory cytokines in the hippocampus of young and old wild-
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Despite all efforts for development
2021-12-10
Despite all efforts for development of reliable laboratory methods, according to WHO/UNAIDS technical update on HIV incidence assays, none of the assays evaluated by Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA) have completely met the criteria for an incidence assay
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The combination of HIV antigen and
2021-12-10
The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window Reparixin for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo assay has a
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Our results demonstrated that most of the
2021-12-10
Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b
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br Conclusions br Acknowledgements This work was supported b
2021-12-10
Conclusions Acknowledgements This work was supported by grants from the Polish National Science Center: 2014/14/E/NZ1/00139 (to A. Jazwa-Kusior) and 2015/17/N/NZ1/00041 (to M. Tomczyk) and National Centre for Research and Development (STRATEGMED2/269415/11/NCBR/2015) (to J. Dulak). Faculty of
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In an effort to further
2021-12-10
In an effort to further improve the intrinsic potency, we evaluated the effect of the C4-substituent of the triazole (). Replacement of the phenyl group with a cyclohexyl or with a 2-pyridyl substituent led to losses in potency. Increasing the size of the substituent to a bi-phenyl or naphthyl group
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br Introduction Marijuana remains the most widely used illeg
2021-12-09
Introduction Marijuana remains the most widely used illegal drug (Murray et al., 2007), and its validated targets include plasma membrane cannabinoid receptors, many of which are found in the central nervous system. The diverse physiological effects produced by marijuana and cannabinoid ligands s
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A subsequent modeling study by a different group was
2021-12-09
A subsequent modeling study by a different group was based on the bovine rhodopsin homology model using the 1L9H construct [38]. However, the site-directed mutagenesis data and docking suggested that the niacin-binding pocket is different to that described in the aforementioned report, but similar t
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Generally speaking the regulation of GnIH on
2021-12-09
Generally speaking, the regulation of GnIH on gonadotropins synthesis and release, although controversial, could be direct and/or indirect via GnRH, among others peptides. In this sense, different scenarios have been reported in vertebrates. In mammalian and avian species, GnIH fibers reach the medi
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