• Phosbind Biotin for Protein Phosphorylation Analysis

  2026-09-04

  Phosbind Biotin enables sequence-independent Western Blot detection of phosphorylated proteins without relying on phospho-specific antibodies. Its biotin–streptavidin-HRP workflow is particularly useful for comparing phosphorylation changes in plant drought-response models and signal transduction pathway research.

• Biomimetic CaCO3 Nanoparticles for GBM Sono-Immunotherapy

  2026-09-03

  Zhao et al. developed cRGD-modified cancer-cell-membrane-coated calcium carbonate nanoparticles to deliver IL-12 mRNA to glioblastoma and combine ultrasound-induced necroptosis with immune stimulation. The study offers a mechanistic framework for integrating blood–brain barrier navigation, localized mRNA expression, and immunogenic tumor-cell destruction, while also highlighting the need for rigorous delivery and expression controls.

• SNAI1–PIK3R2/p-EphA2 Axis in Thymic Tumors

  2026-09-03

  This 2024 study identifies SNAI1 as a transcriptional hub that promotes epithelial–mesenchymal transition and sustains cancer stem cell-like traits in thymic epithelial tumors through the PIK3R2/p-EphA2 axis. Integrated transcriptomic, epigenomic, single-cell, phosphoproteomic, and functional assays connect tumor-cell plasticity with macrophage-state changes, supporting SNAI1 as a mechanistically grounded therapeutic research target.

• Acifran: From Cryo-EM Structure to Assay Design

  2026-09-02

  Acifran is a structurally informative agonist for HCAR2/GPR109A and HCAR3/GPR109B research. This guide connects cryo-EM evidence with practical assay design, helping researchers distinguish receptor engagement, pathway activity, and apparent selectivity in lipid metabolism studies.

• QSHXO, Autophagy, and Ferroptosis in MASLD

  2026-09-02

  A 2026 World Journal of Hepatology study identifies coordinated autophagy activation and ferroptosis inhibition as a mechanistic basis for Qushi Huoxue ointment activity in a mouse model of metabolic associated steatotic liver disease. Its multi-method design links lipid and inflammatory improvement with changes in autophagy markers, Nrf2 signaling, iron deposition, and mitochondrial ultrastructure, while also highlighting important limits of model-based interpretation.

• SIS3: Precision Control of Smad3 in Translational Research

  2026-09-01

  SIS3 is a selective Smad3 inhibitor that enables researchers to separate Smad3-dependent TGF-β signaling from broader pathway effects. This thought-leadership guide connects its mechanism to fibrosis research, renal disease models, and osteoarthritis evidence, while outlining practical strategies for rigorous translational study design.

• EGCG Nanoparticles Enhance FLASH Radiotherapy

  2026-09-01

  Xu et al. developed functionalized, self-assembled EGCG nanoparticles (BENPs) to increase ROS generation, DNA damage, and tumor-cell killing during FLASH radiotherapy. In a 4T1 breast tumor model, the combination also stimulated antitumor immune features, although further work is needed to establish pharmacokinetics, optimal dosing, and clinical transferability.

• SIRT1/2 Inhibitor IV: Applied Research Workflows

  2026-08-31

  Build mechanism-focused assays around SIRT1/2 Inhibitor IV (cambinol) to connect deacetylase activity with lactate signaling, Ran modification, p53 acetylation, and tumor-cell responses. This practical guide separates evidence-backed observations from starting conditions for CNS injury, cancer, and metabolic pathway experiments.

• Masitinib (AB1010): KIT/PDGFR Workflow Guide

  2026-08-31

  Masitinib (AB1010), SKU A2942, is a DMSO-compatible phenylaminothiazole-type kinase inhibitor for workflows involving KIT, PDGFRα, PDGFRβ, mast cells, and selected cancer models. It is not suitable for aqueous or ethanol-based protocols, broad-spectrum kinase screens, or clinical treatment decisions without independent evidence and validation.

• HNF4A-AS1 and Sorafenib Resistance in HCC

  2026-08-30

  A 2024 Theranostics study identifies the liver-enriched lncRNA HNF4A-AS1 as a regulator of sorafenib-induced ferroptosis in hepatocellular carcinoma. Its mechanistic model links HNF4A-AS1 to METTL3-dependent m6A modification of DECR1 mRNA, polyunsaturated fatty acid retention, and drug sensitivity.

• CD36 Lipid Signaling Drives Immune Escape in AML

  2026-08-29

  Guo et al. identify a non-canonical CD36 lipid-sensing program in AML that links oxidized LDL and palmitate uptake to innate immune signaling, T-cell suppression, and resistance to decitabine. The study provides a mechanistic rationale for combining hypomethylating therapy with lipid-restriction strategies, while also defining important limits for translating the findings into other immunometabolic models.

• CD36 Lipid Signaling Drives Immune Escape in AML

  2026-08-28

  Guo et al. identify a non-canonical CD36-dependent lipid-signaling program in acute myeloid leukemia that links oxidized LDL and palmitate uptake to T cell suppression and resistance to decitabine. The study suggests that statin-mediated disruption of leukemic CD36 signaling may improve hypomethylating-agent efficacy, while also defining important metabolic and immunologic variables for future AML studies.

• Metoprolol Research Workflows for Beta1 Assays

  2026-08-28

  Build reproducible beta1-receptor, cardiovascular, inflammation, and exploratory tumor-biology assays with a defined small-molecule perturbation. This guide combines fresh-solution handling, concentration-response design, disease-state pharmacokinetic thinking, and troubleshooting strategies for Metoprolol BA2737.

• Temozolomide Workflows for Glioma DNA Damage

  2026-08-27

  Temozolomide provides a controlled way to impose DNA methylation stress in glioma and other cancer models. This guide connects practical dosing, ATRX-stratified combination assays, and troubleshooting strategies for DNA repair mechanism research and chemotherapy resistance studies.

• Central Control of Opioid Mechanical Hypersensitivity

  2026-08-27

  A 2024 Neuron study identifies a brain-to-spinal pathway linking MOR-expressing neurons in the lateral parabrachial nucleus to dynorphin and KOR-GABA circuits that regulate morphine-induced mechanical hypersensitivity and analgesic tolerance in mice. The findings distinguish mechanical opioid side effects from better-established thermal mechanisms and provide a circuit framework for receptor-specific pain mechanism research.

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