• br A KCNJ mutation corresponding to an S L

  2019-04-15

  

  A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6

• Introduction Atrial fibrillation AF is the

  2019-04-15

  

  Introduction Atrial fibrillation (AF) is the most common arrhythmia in adults and the most common cause of embolic stroke. AF affects approximately 0.8 million patients in Japan alone, and its incidence is expected to grow exponentially [1–3]. However, the electrophysiological mechanisms of the ini

• stat 3 inhibitor Adhesive interactions Adhesive interactions

  2019-04-15

  

  Adhesive interactions: Adhesive interactions between myeloma stat 3 inhibitor and stromal cells play a significant role in both the homing of MM cells to the bone marrow and augmentation of the bone destructive process. These adhesive interactions result in activation of NF-κB and p38 MAP-kinase si

• Both breast cancer and MM cause osteolytic lesions inhibitin

  2019-04-15

  

  Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit

• Heat shock facilitates the folding of various proteins

  2019-04-15

  

  Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is

• br Chronic obstructive pulmonary disease COPD remains a

  2019-04-15

  

  Chronic obstructive pulmonary disease (COPD) remains a major public health problem. The was first published by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in 2001. A major revision was undertaken in 2011 and an update to it was published in February this year. The Chinese So

• br The Global Burden of Disease Study notes a

  2019-04-15

  

  The Global Burden of Disease Study notes a substantial decrease in long-established global health threats such as communicable diseases and malnutrition, while underscoring the rise in non-communicable diseases and years lived with potentially disabling illnesses and injuries. One important but la

• MK2 inhibitor Vaccinated individuals might represent a safer

  2019-04-15

  

  Vaccinated individuals might represent a safer source of hyperimmune serum. Two vaccine candidates will be tested soon in west Africa. If serum from vaccinated individuals has neutralising activity against the virus in cell models, this serum could be used as adjuvant therapy for EVD. In parallel, a

• br Discussion Variant angina was described

  2019-04-15

  

  Discussion Variant endothelin receptor was described by Prinzmetal et al. in 1959 [1]. It can involve serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrioventricular block, and patients are particularly susceptible to sudden cardiac death in such cases [2,3].

• br Discussion It is generally known that primary CNS melanom

  2019-04-15

  

  Discussion It is generally known that primary CNS melanomas are rare and difficult to diagnose prior to biopsy. According to tumor melanin content, four subtypes of malignant intracranial melanoma have been proposed, associated with different MRI image presentations. These subtypes are: 1) melano

• After the RFCA neither sustained VT

  2019-04-11

  

  After the RFCA, neither sustained VT nor the VPCs that triggered the VT were recorded. The patient was fitted with a WCD (LifeVest, Zoll, Pittsburgh, PA, USA) on the third day post-ablation, and sotalol 80mg a day was started. He was discharged from the coronary care unit the following day. During c

• External parties ability and willingness to fund health inte

  2019-04-11

  

  External parties\' ability and willingness to fund health interventions is also an important factor in how governments decide on their spending priorities. Historically, development partners have funded prevention and treatment for a key group of diseases. Furthermore, a diverse set of barriers prev

• histamine dihydrochloride Motivation and significance The im

  2018-11-15

  

  Motivation and significance The imaging method of seismic full waveform histamine dihydrochloride (FWI) aims at utilizing the complete information content of measured seismic waveforms for deriving an earth model. Established methods iteratively derive a series of models converging to the solutio

• Self rated health SRH is a

  2018-11-15

  

  Self-rated health (SRH) is a subjective perception and has become an increasingly common measure for public health monitoring. SRH is a strong independent predictor of mortality after accounting for objective health status, behavioral risk factors and socio-demographic characteristics, and it also p

• EPISONO is an epidemiological sleep study that

  2018-11-15

  

  EPISONO is an epidemiological sleep study that was performed with a sample representing the São Paulo population in 2007. All volunteers were submitted to a single night polysomnography on sleep laboratory and to complete questionnaires before and after exam, one of these questionnaire was about SB

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