The following are the supplementary data related

2018-10-20

The following are the supplementary data related to this article. Conflict of interest Introduction Mammalian eyes contain retinal stem cells (RSCs) that are capable of proliferating and differentiating into all of the cell types of the neural retina as well as the retinal pigmented epitheliu

Chemotherapy is a standard treatment for

2018-10-20

Chemotherapy is a standard treatment for patients with advanced disease, including nonresectable, recurrent, or metastatic tumors. Due to chemoresistance, the majority of patients die within three years (Papaspyrou et al., 2011). Indeed, cisplatin and other platinum-based therapies do not present cl

IOX2 There has been controversy regarding whether subsets

2018-10-20

There has been controversy regarding whether subsets of premigratory neural crest IOX2 are predetermined to form distinct cell types or multipotent and capable of forming numerous derivatives. Recently, this has been elegantly put to rest by single cell lineage analysis using Confetti transgenic mi

calcitonin receptor EWS FLI a widely recognized fusion oncog

2018-10-20

EWS-FLI1, a widely recognized fusion oncogene for Ewing sarcomas, is generated by the chromosomal translocation of t(11;22) (q24;q12), which consists of the N-terminal transactivator domain of the EWS gene and the C-terminal ETS DNA binding domain of the FLI1 gene. The resulting EWS-FLI1 fusion prot

To address this issue we examined

2018-10-20

To address this issue, we examined striatal neurons innervated by nigral DA neurons using the plant lectin wheat-germ agglutinin (WGA). WGA can be efficiently transferred between neurons via synapses and has been already used as a transsynaptic tracer (Fabian and Coulter, 1985; Broadwell and Balin,

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We are grateful for the support from ES/iPSC core facility, Lund University. This work was funded by grants from: The Swedish Research Council, Swedish Cancer Society, Swedish Children\'s Cancer Society, AFA Insurance (Sweden), Lu

The experimental design of this model provides

2018-10-20

The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

Despite the dramatic changes in

2018-10-20

Despite the dramatic changes in bone morphology in OsxCre;iDTR mutants, bone marrow cellularity was unaffected compared with their control littermates (Figure 3A). Red blood cell and platelet numbers were unchanged in the blood of the OsxCre;iDTR mutant, but there was a 50% decrease in the white blo

Hippocalcin HPCA is a high affinity calcium

2018-10-20

Hippocalcin (HPCA) is a high-affinity calcium-binding protein restricted to the CNS and is most abundant in pyramidal cells of the hippocampus CA1 region (Kobayashi et al., 2012). During brain development HPCA expression increases sharply, concurrent with synapse formation (Saitoh et al., 1994). HPC

Dedifferentiation has been considered as one of the mechanis

2018-10-20

Dedifferentiation has been considered as one of the mechanisms rerouting cell fate by reverting differentiated cells to an earlier, more primitive phenotype. Interestingly, previous studies from both our group and others have demonstrated that dedifferentiation is a prerequisite for bone marrow stro

Hello world!

2018-07-29