• In order to assess the

  2018-11-08

  

  In order to assess the cellular proliferation potential colony forming efficiency was determined. As we decided to apply a low suction vacuum pressure in order to minimize potential discomfort during bone marrow harvest under local anesthesia in the control individuals the achieved mean cell yields

• br Acknowledgements br Resource table br Resource details

  2018-11-08

  

  Acknowledgements Resource table Resource details To generate the Saudi KACST induced Pluripotent Stem Cell line No 1 (SKiPSc1) cell line, four reprogramming Yamanaka factors (Oct3/4, Sox2, c-Myc, and Klf4) (Takahashi et al., 2007; Yu et al., 2007) were delivered to HNFFs by Sendai viral inf

• br Materials and methods br Acknowledgments We

  2018-11-08

  

  Materials and methods Acknowledgments We would like to thank Dr. Saran Karumbayaram for providing guidance in the culture and expansion of the primate fibroblasts. We would also like to thank Steven Dowdy for depositing the T7-VEE-OKS-iG plasmid (Addgene). This project was funded by NIH grant

• silybin Induction of EndMT results from integration of multi

  2018-11-08

  

  Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

• To examine the functional role of IGFBP

  2018-11-08

  

  To examine the functional role of IGFBP-2 and -3 we conducted the experiments described in Fig. 4 where the effects of IGFBP-2 and -3 were examined either uncomplexed or complexed with IGF1. The data indicated that IGF1 stimulated ALP activity in DPCs in a dose dependant manner and although there we

• It was recently shown that hPSCs can

  2018-11-08

  

  It was recently shown that hPSCs can be expanded as cell-only dnmt in serum-free suspension culture irrespective of matrix supplementation (Amit et al., 2011; Olmer et al., 2010; Singh et al., 2010), which is mandatory for conventional surface-attached propagation of hPSCs. In contrast to matrix-at

• Studies from other glandular tissues like mammary gland reve

  2018-11-08

  

  Studies from other glandular tissues, like mammary gland, revealed CD24hi/CD29lo- (Shackleton et al., 2006) expressing NVP-TNKS656 as potential stem cells. In mice, we reported that intraglandular transplantation of primary-sphere-derived CD24+/CD29+ cells could ameliorate radiation-induced hyposali

• The Xenopus homolog of Bucky

  2018-11-08

  

  The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

• Since the donor hESC derived cells are allografts there

  2018-11-08

  

  Since the donor hESC-derived order Alvespimycin are allografts, there is the possibility of graft rejection after transplantation. Previous allogeneic RPE cell transplantations in dry AMD resulted in graft rejections in some cases, although it started later in the treatment course and was seen less

• br Introduction The adult prostate gland contains a simple c

  2018-11-08

  

  Introduction The adult prostate gland contains a simple columnar epithelium composed of luminal secretory and underlying basal PCP inhibitor with a scarce neuroendocrine cell component. These epithelial cells are derived from a rare, relatively quiescent stem cell population that maintains gland

• Although our results suggest that Ronin

  2018-11-08

  

  Although our results suggest that Ronin directly impacts DNA repair through the transcriptional regulation of DNA repair genes, we further sought to determine how much the canonical pluripotency factors might contribute to the transcriptional regulation of DNA repair genes. Oct4 and Sox2 are known t

• lipoxygenase We generated immortalized BMSC clones to perfor

  2018-11-08

  

  We generated immortalized BMSC clones to perform detailed analysis of functional diversity in BMSC subtypes to levels not previously described. Similar immortalization techniques (e.g., hTERT combined with human papillomavirus E6/E7) have been used for the clonal analysis of BMSCs, which found OAC,

• A live newborn with full

  2018-11-08

  

  A live newborn with full trisomy 12 was never reported, suggesting that it is embryonic lethal in humans. However, individuals carrying mosaic tetrasomy of 12p were reported showing a variety of abnormalities (Segel et al., 2006). This condition, known as Pallister-Killian mosaic syndrome, is extrem

• Disease modeling with iPSCs can be challenging due

  2018-11-08

  

  Disease modeling with iPSCs can be challenging due to inherent patient variability and line-to-line differences (Hu et al., 2010; Boulting et al., 2011). Importantly, very few differences were observed among the three independent control lines. The SNCA (3×) iPSC line was not different from controls

• Several approaches exist to prevent allogeneic cell

  2018-11-08

  

  Several approaches exist to prevent allogeneic cell transplantation-related immune rejection. One is immune suppression therapy using a combination of several different types of immunosuppressants. Others are the use of major histocompatibility complex (MHC)-matched donor cells to reduce immunogenic

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