• br Space syntax method for interpreting mosque layouts The s

  2018-11-12

  

  Space syntax method for interpreting mosque layouts The space syntax method is an approach developed to analyze spatial configuration. Space syntax aims to describe spatial models (e.g., mosque layouts) and represent these models in numerical and graphical forms, thus facilitating scientific inte

• Limitations of the preceding discussion include an inability

  2018-11-12

  

  Limitations of the preceding discussion include an inability to adroitly compare and contrast the esthetic content of the visual, non-written material embedded in each submittal. This is because conventional content analysis methodology is dependent upon written texts. In order to develop a comparab

• br Patients and methods All

  2018-11-12

  

  Patients and methods All patients were diagnosed with HCC after surgery between 1998 and 2006 and followed-up for at least 5 years. The laparoscopic or traditional liver resection procedures were performed following the clinical practice guidelines. The indications for laparoscopic liver resectio

• Associated hyperostosis of the anterior skull

  2018-11-12

  

  Associated hyperostosis of the anterior skull tachykinin receptor is extremely rare for patients with ENBs. Meningioma-associated hyperostosis is relatively common, generally localized, and proportional to the tumor size; the potential pathogenesis of tumor-associated hyperostosis was considered to

• br Discussion Anastomotic aneurysm formation following extra

  2018-11-12

  

  Discussion Anastomotic aneurysm formation following extracranial-intracranial (EC-IC) surgery is relatively uncommon. In previously reported cases (Table 1), pseudoaneurysm formation was mostly observed during the first 2 postoperative months, whereas true aneurysms were observed years after surg

• The conflicting findings of Jensen et al and Odunsi

  2018-11-12

  

  The conflicting findings of Jensen et al. [31,33] and Odunsi et al. [34] may be the result of different modes of alginate delivery. The greater volume of drinks compared to the volume of capsules may stimulate gastric stretch receptors, increase satiety and therefore reduce energy consumption. El K

• The cells used in our studies appear

  2018-11-12

  

  The ezh2 pathway used in our studies appear reliably over time in primary hepatocyte cultures in the presence of growth factor supplemented medium and were first described as BAML cells [6]. Whether they already pre-exist as stem/progenitor cells in the liver or derive from other cell types in the

• br Conclusion br Materials and methods

  2018-11-12

  

  Conclusion Materials and methods Acknowledgments We thank M. Dubrovcakova and V. Frivalska for excellent technical assistance. We are grateful to J. Zmajkovic for technical help with fluorescence microscopy, J. Lakota, M.D. for providing us with material and M. Cihova for critical reading o

• Microarray data was validated using quantitative PCR qPCR

  2018-11-12

  

  Microarray data was validated using quantitative PCR (qPCR). This was first performed on a set of genes chosen for their wide variation in gene Barasertib between the three cell types (Prl2c2, GHR, Zyx, Des) (Supplementary Figure S2). qPCR was then performed to validate the expression of genes rega

• Bystander effect between HSVtk positive cells and HSVtk nega

  2018-11-12

  

  Bystander effect between HSVtk-positive cells and HSVtk-negative cells has been extensively studied especially from the aspect of cell-to-cell communication. Connexin43, a major molecule in the connexin family gene products, has been reported to be related to the bystander effect in suicide gene the

• While stem cell based therapies

  2018-11-12

  

  While stem cell-based therapies hold great potential for the treatment of a wide array of medical conditions they are so novel that product characterization is particularly challenging. Despite considerable progress, the molecular regulatory mechanisms of self-renewal and lineage specification in th

• Because Foxd regulates stem cell

  2018-11-12

  

  Because Foxd3 regulates stem cell properties in multiple lineages (Liu and Labosky, 2008; Hanna et al., 2002; Mundell et al., 2012; Mundell and Labosky, 2011; Teng et al., 2008; Tompers et al., 2005), Foxd3 target genes must regulate self-renewal, pluripotency, and/or survival of stem cells. Current

• br Introduction Pancreatic ductal adenocarcinoma remains one

  2018-11-12

  

  Introduction Pancreatic ductal adenocarcinoma remains one of the most aggressive and devastating tumor malignancies with an overall 5-year survival rate of less than 5% (Kern et al., 2011). The only potentially curative treatment is the complete surgical resection of the tumor. Nevertheless, even

• hESC NPCs and hfNPCs induced different PBMC proliferative re

  2018-11-12

  

  hESC-NPCs and hfNPCs induced different PBMC proliferative responses, despite relatively similar expression levels of HLA, co-stimulatory and adhesion molecules. Multiple other factors that are produced by NPCs and may contribute to the regulation of the immune response such as inducible nitric oxide

• Recently developed LEDGINs small molecule inhibitors

  2018-11-09

  

  Recently developed LEDGINs, small molecule inhibitors of LEDGF/p75–IN interaction, allowed us to test this hypothesis. Indeed here we demonstrate: (i) a LEDGIN-mediated shift in lentiviral integration site distribution resembling LEDGF/p75 depletion (out of the body of actively transcribed genes, wi

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