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Next we compared the protease specificity of
2020-09-02
Next, we compared the protease-specificity of viruses NS116-GFP/AE and NS116-GFP/AT for trypsin, neutrophilic elastase or supernatant of human neutrophils. For later purposes, we determined the viral yield in a co-cultivation system of infected Vero SL-327 mg with human neutrophils. The NS116-GFP/e
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br Orthotopic liver transplantation OLT is the
2020-09-02
Orthotopic liver transplantation (OLT) is the only curative therapy available for patients with end-stage liver disease. The surgical procedure of liver transplantation inherently involves cold ischemia during graft preservation , followed by reperfusion of the transplanted graft which results in
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Pulmonary fibroblasts can regulate the wound healing process
2020-09-02
Pulmonary fibroblasts can regulate the wound healing process by secreting and processing extracellular matrix (ECM), chemokines, and cytokines. However, persistent and atypical fibroblast proliferation can result in ECM accumulation and may trigger the onset or development of pulmonary fibrosis [[17
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Recent studies showed that the
2020-09-02
Recent studies showed that the activity of CK2 was significantly reduced in ischemic stroke model rats, and cerebral I/R injury significantly decreased the expression of CK2α (Lee et al., 2004; Kim et al., 2012; Zhou et al., 2016). In addition, the dysregulation of CK2 is involved in ERS/UPR in non-
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Namely the NOESY cross peaks between
2020-09-02
Namely, the NOESY cross-peaks between H-7″ methylene protons ( 4.01 and 4.16) with H-6′ ( 6.76) revealed that H-2 and OH-3 are -orientated, which indicated that the relative configuration of the C2 and C3 substituents as . For the -isomers, the thermodynamically more stable conformation is when H-2
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Palomid 529 Patients and methods This study was performed at
2020-09-02
Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards
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br Cytokine impact on ILC
2020-09-02
Cytokine impact on ILC fate Increasing evidence shows that ILC2 and ILC3 may convert into ILC1-like Mouse Erythropoietin / EPO Protein by downregulating either GATA3 or RORγt, respectively, upregulating T-bet and gaining the capacity for IFN-γ production [60,61]. This process, often referred to
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Dehydrogenation by a KSTD is also a
2020-09-01
— 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during smo inhibitor degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroid d
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Previously the N glycan in V of HXB HXB
2020-09-01
Previously, the N-glycan in V3 of HXB2, HXB10, LAI and BRU strains was reported to be dispensable for their infectivity to T cell lines, although detailed growth kinetics and experimental conditions were not described 4, 5, 6, 7, 8. The experiments appear to have been done by infection initiated wit
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This review focuses on the
2020-09-01
This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t
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It has previously been shown that human melanocytes are
2020-09-01
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Pirfenidone on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that th
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Because conventional KO mice die
2020-09-01
Because conventional KO mice die within 24h of birth, it is difficult to analyze higher cid calculator functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discussion
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br Introduction Malaria remains a serious parasitic
2020-09-01
Introduction Malaria remains a serious parasitic disease in tropical areas due to its high morbidity and mortality rates. It is estimated that 212 million cases occurred globally in 2015, leading to 429, 000 deaths, most of which were in children aged under 5 years in Africa [1,2]. The protozoan
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br Methods br Results Main characteristics of study populati
2020-08-31
Methods Results Main characteristics of study population are presented in Table 1. AD cases had higher co-morbidity score and lower socioeconomic position than controls. Women with AD had undergone any surgery (unilateral/bilateral oophorectomy, hysterectomy, hysterectomy with bilateral oophor
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Three kinase inhibitors dasatinib type
2020-08-31
Three kinase inhibitors dasatinib (type I), imatinib (type II) and nilotinib (type II), identified initially as inhibitors of tyrosine kinase BCR-ABL, were found to target DDRs in a chemical proteomic profiling study (Bantscheff et al., 2007, Hantschel et al., 2008). These tyrosine kinase inhibitors
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