• This hypothesis is in line

  2022-07-12

  

  This hypothesis is in line with our phylogenetic analysis of FBPase sequences which revealed that vertebrate FBP2 evolved significantly faster than FBP1 (Fig. 2). An average distance between FBP2 and ancestral vertebrate FBPase was higher than that for FBP1. Moreover, preliminary study on amphibia

• Previously we have isolated liver FBPase from Pelophylax

  2022-07-12

  

  Previously we have isolated liver FBPase from Pelophylax esculentus (former Rana esculenta, Frost et al., 2006) and characterized its kinetic properties (Dziewulska-Szwajkowska and Dzugaj, 1999) on the contrary the muscle FBPase has never been fully characterized. The primary aim of the present pape

• There are limited studies on antibody

  2022-07-12

  

  There are limited studies on antibody responses against HIV-1 integrase antigen. According to previous studies, almost 5 percent of individuals infected with HIV never raise anti-integrase Pertussis Toxin (Rikhtegaran Tehrani et al., 2015; Chang et al., 1985). If this rate is identical in individua

• Nevertheless the frequency of CTCs was higher

  2022-07-12

  

  Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer nordihydroguaiaretic acid from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC count

• Importantly other aspects of platelet function aggregation

  2022-07-12

  

  Importantly, other aspects of platelet function (aggregation, spreading, in vitro and in vivo thrombosis) important for haemostasis and thrombosis were unaltered in Ral DKO platelets and mice. Beyond haemostasis and thrombosis however, platelets have been implicated in numerous pathophysiological pr

• The first report of GUCY D related gene augmentation

  2022-07-12

  

  The first report of GUCY2D-related gene augmentation therapy in mammalians was also reported in 2006 in the KO mouse model (section 4.1.1). In this study, an AAV5 vector by using AAV5-mediated transfer of the bovine cDNA (the same used in the chicken study) was injected to the post-natal KO retina a

• The compounds f and a

  2022-07-12

  

  The compounds 8f and 9a–e were found to be potent inhibitors of both isoforms of GSK-3 as characterized by IC50 values in the low nanomolar range. In addition, all of them showed good selectivities against other kinases. Substituents in the ortho- and para-positions of structure 8 and 9 lead to pote

• Introduction The onset of uterine labor

  2022-07-12

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• br Acknowledgments br Introduction Myelin one of the

  2022-07-12

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the 2-MeOE2 mg of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC) in t

• br Acknowledgments This publication was

  2022-07-12

  

  Acknowledgments This publication was supported by NORAD (Norwegian Agency for Development Cooperation) under the NORHED-Program, agreement no. ETH-13/0024. MCM works at the MRC Integrative Epidemiology Unit which receives infrastructure funding from the UK Medical Research Council (MRC) (MC_UU_12

• br Expression of GlyT in the

  2022-07-11

  

  Expression of GlyT in the spinal cord in response to neuropathic pain Twelve days after sham injury or CCI, GlyT1 and GlyT2 mRNA expression in rat spinal cord was analyzed using qPCR. Here, no significant changes in expression of the transporters in our CCI model of neuropathic pain compared with

• toremifene citrate Conformational changes are observed in

  2022-07-11

  

  Conformational changes are observed in the LBDs after ligand binding, including partial cleft closure for GluN2A and complete cleft closure for GluN1. For GluN2A, additional conformational rearrangements in the protein and ligand may be required before the ligand can be accommodated within lobe 2. F

• Recent studies suggested that non coding RNAs participate in

  2022-07-11

  

  Recent studies suggested that non-coding RNAs participate in the modulation of Glut1 expression. For instance, the lncRNA NBR2-Glut1 axis was suggested to modulate cancer cell sensitivity to phenformin [37]. In renal carcinoma, miR-1291 is involved in the regulation of Glut1 n methyl d aspartic acid

• Administration of a fructose rich diet to normal rats

  2022-07-11

  

  Administration of a fructose-rich diet to normal rats induces insulin resistance and impaired glucose tolerance or diabetes, depending on treatment duration [23]. We have shown that development of these abnormalities as well as fat deposit in liver, are effectively prevented by co-administration of

• In conclusion enhanced glucagon action of the

  2022-07-11

  

  In conclusion, enhanced glucagon action of the beta cell results in improved beta cell function after glucose stimulation, but simultaneously dissociated responses to both glucose-dependent and non-glucose secretagogues evolve. This shows that the glucagon receptor is complexly involved in beta cell

15311 records 343/1021 page Previous Next First page 上5页 341342343344345 下5页 Last page