• br Conflict of interest statement

  2024-04-10

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal herpes simplex virus 2 in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 c

• Having taken a step back from affinity

  2024-04-10

  

  Having taken a step back from affinity to gain better exposure and solubility, we started work to replace the unstable oxazolinone, and address the selectivity over the hERG channel. Keeping in mind the binding mode of the series from crystal structures, triazole was identified as another mildly aci

• AUY922 synthesis Acknowledgments br Introduction Prostate ca

  2024-04-10

  

  Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi

• br Experimental br Results and

  2024-04-10

  

  Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP

• The crucial role of AP in establishing and maintaining

  2024-04-10

  

  The crucial role of AP-1 in establishing and maintaining cell type-specific gene expression programs and cell identity is further apparent during reprogramming of mouse embryo fibroblasts (MEFs) into iPSCs with either Oct4/Sox2/Klf4/cMyc (OSKM ) factors , or chemicals . Using ATAC-seq to profile ch

• br Economics consequences of antibiotic resistance in a SICU

  2024-04-10

  

  Economics consequences of antibiotic resistance in a SICU In the era of cost-containment, surgeons also need to consider the economic impact of antibiotic resistance in the surgical patient. Antibiotic-resistant infections are more difficult to treat, are more costly and more likely to be fatal t

• A phase I trial has recently evaluated enzalutamide

  2024-04-10

  

  A phase I trial has recently evaluated enzalutamide, an anti-androgen agent, in patients with ER- and AR-positive advanced BC to estimate safety and tolerability of enzalutamide therapy alone or in association to anastrozole, exemestane or fulvestrant [65]. The results of major clinical trials with

• Besides the described changes in

  2024-04-09

  

  Besides the described changes in protein expression and thus in current amplitudes, TAK-715 of PORCN also leads to accelerated decay kinetics of evoked and spontaneous AMPAR currents. These changes in channel kinetics are most likely a secondary effect due to the selective depletion of γ-8 but not

• Since HETEs and lipoxins the downstream products

  2024-04-09

  

  Since HETEs and lipoxins, the downstream products of 12/15-LOX from AA, may alter cellular proliferation and apoptosis,31, 32 and possibly explain the increase of tumour progression and metastasis. However, we here found that HETEs did not affect the proliferation of melanoma in vitro. This may part

• Recently rather than predicting categorical variables

  2024-04-09

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from PD173955 images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regression focus on

• Liaohe River situates in the southwestern part of Northeast

  2024-04-09

  

  Liaohe River situates in the southwestern part of Northeast China and flows through Liaoning Province. Due to the rapid urbanization and industrialization, Liaohe River has become one of the most polluted rivers in China. Multitudinous organic pollutants that can induce toxicity to organisms such as

• br Conflict of interest br Acknowledgments This work was sup

  2024-04-09

  

  Conflict of interest Acknowledgments This work was supported by research grant [PR26/20326] from Santander Bank/UCM. The authors would like to thank Miguel Capo, Professor of Toxicology from the Universidad Complutense de Madrid, for his counseling during the preparation of the present work.

• The difficulty of characterizing nAChRs in

  2024-04-09

  

  The difficulty of characterizing nAChRs in the central nervous system is also exemplified by early observations that nicotine caused no detectable effect when applied on a brain slice and it is only with the focal and high time resolution of more recent experiments that the effects of nicotinic neur

• Physiology genetics and biochemistry of

  2024-04-09

  

  Physiology, genetics, and LY500307 receptor of CYP17A1 Clinical presentation and diagnosis Treatment Acknowledgements I thank Dr. Hwei-Ming Peng for assistance with preparing Fig. 3. This work was supported by grant R01GM086596 from the National Institutes of Health. Introduction Pros

• br Introduction Stroke is a devastating condition that cause

  2024-04-09

  

  Introduction Stroke is a devastating condition that causes cognitive and motor dysfunction, neurodegenerative diseases and even acute death, and is a leading cause of mortality and morbidity worldwide (Chen et al., 2014a, Wang et al., 2016). Thus, exploration or identification of novel therapeuti

14621 records 130/975 page Previous Next First page 上5页 126127128129130 下5页 Last page