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br Acknowledgments We thank the Lapaha
2020-07-30
Acknowledgments We thank the Lapaha Community and Nobles (His Serene Highness Prince Kalaniuvalu Fotofili, Her Serene Highness Princess Marcella Taumoepeau Tupou Kalaniuvalu Fotofili and Her Royal Highness Mele Siu\'ilikutapu Kalaniuvalu Fotofili) and the Ministry of Internal Affairs (Government
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br Overall architecture of the proposed recommender system
2020-07-30
Overall architecture of the proposed recommender system In this section we describe the overall architecture of the proposed recommender system. Although dozens of recommender systems in software engineering have been built, no reference architecture has emerged to-date (Robillard et al., 2014).
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While a complete review of the molecular
2020-07-29
While a complete review of the molecular mechanisms regulating mammalian DGK activities is beyond the scope of this review, other reviews have covered much of this aspect (Shulga et al., 2011a; Topham and Epand, 2009; Tu-Sekine and Raben, 2011). In general, aside from enzyme 28170 levels, this regu
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Calmodulin CaM is a multifunctional calcium transducer It fu
2020-07-29
Calmodulin (CaM) is a multifunctional calcium transducer [8]. It functions as a central regulator of cellular metabolism in response to changes in cellular calcium levels by interacting with various targets [9]. Numerous studies have been devoted to the understanding CaM mechanism of action. Early m
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Here we use RNA sequencing RNA seq chromatin
2020-07-29
Here, we use RNA sequencing (RNA-seq), chromatin immunoprecipitation sequencing (ChIP-seq) and rapid amplification of cDNA ends (RACE) to map the human SYNE1 transcriptome, providing a framework for localizing the multiple disease-associated mutations identified in this complex gene in relation to s
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Our results on the acute effects of
2020-07-29
Our results on the acute effects of THC on resting state SC 79 function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et al., 2002, van Hell
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Programmed cell death via apoptosis is associated with a ser
2020-07-29
Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap
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Introduction Angiotensin II Ang II and
2020-07-29
Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto
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In addition to the receptor TGF also regulates the DDR
2020-07-28
In addition to the receptor, TGF-β1 also regulates the DDR1 ligand meaning the type I collagen and the enzyme involved in its maturation (LOXL2). We previously demonstrated that an increase of type I collagen concentration is associated with the presence of more linear invadosomes in lipid metabolis
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Asthma pathogenesis involves not only
2020-07-28
Asthma pathogenesis involves not only acute airway obstruction, but also chronic eosinophilic airway inflammation including airway hyperresponsiveness. It is unclear whether antagonism of CysLT2 receptors would results in anti-inflammation in hydroxychloroquine sulfate patients. Further studies of
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To confirm and extend those findings of a differential inter
2020-07-28
To confirm and extend those findings of a differential interaction between hCrm1 and mCrm1 and Rev-RRE, we first attempted to use the yeast two and three hybrid systems, but failed to observe a detectable interaction between any of the Crm1s and Rev, in the presence or absence of HIV RRE RNA. We the
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Of CE ribotyping profiles were recognized only by the
2020-07-28
Of 53 CE-ribotyping profiles, 24 were recognized only by the WEBRIBO database and these isolates comprised 11.2% (n=247) of our collection. The occurrence of several WRTs identified in our study (209, 220, 404, 416, 438, 500, 555, AI-12, AI-20, AI-21, AI-75, AI-9-1) has been reported as human clinic
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br Long lasting agonism Conditions of
2020-07-28
Long-lasting agonism Conditions of dynamic equilibrium govern most classical and modern theories of molecular pharmacology [44]. These conditions do not easily apply to ETA in view of the slow dissociation of the agonist–receptor complex 4, 31, 45, 46. Hence, reported affinity measures (e.g. the
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In order to verity if the
2020-07-28
In order to verity if the N&B method is able to detect any variation in AT1EYFP and ETAEGFP receptors aggregation propensity due to exogenous treatments in living cells, they were treated by the endogenous peptides Ang II and ET-1, as well as the selective receptors antagonist losartan, BQ123 and si
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In the context of E
2020-07-27
In the context of E3 ligase drug discovery, it is critical to identify the appropriate E2/E3 substrate pairing to ensure the development and use of the most physiologically relevant screening assay. There have been many reports of limited E2/E3 activity profiling with a small number of E2 and E3 mel
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