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br The lipoxygenase pathway and microvascular complications
2024-02-21
The 12/15-lipoxygenase pathway and microvascular complications of diabetes The 12/15-lipoxygenase pathway in adipose tissue Only recently has adipose tissue been recognized as a highly metabolically active endocrine organ imparting profound local and systemic inflammatory effects. Adipose tiss
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br The lipoxygenase pathway in diseases of the nervous
2024-02-21
The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic QS 11 and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functions of 12- and 15
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Mitochondria from frozen thawed bull sperm are capable of
2024-02-21
Mitochondria from frozen-thawed bull sperm are capable of producing energy using pyruvate and lactate as substrates through oxidative pathways (Beorlegui et al., 1997). Based on the present study, heparin capacitated sperm had a lesser lactate concentration in the incubation medium, supporting the h
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Endogenous adenosine systems have largely been implicated in
2024-02-21
Endogenous adenosine systems have largely been implicated in drug actions by the demonstration that caffeine (non-selective A1R and A2AR antagonist) (see Section The issue of caffeine), in doses up to 7.5–10mg/kg, inhibits antinociception, and when this occurs, it KB-R7943 mesylate is generally als
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br Perspectives Given the complexity of the
2024-02-21
Perspectives Given the complexity of the cellular interactome and of protein scaffolding, further progress in revealing how individual membrane proteins, including APP and AChE, interact with each other at various levels, from cell-surface shedding to gene regulation, will clarify some intrinsic
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br Conclusions In summary the present results showed that
2024-02-21
Conclusions In summary, the present results showed that ageing diminished arginase activity only in clearance tissues and that l-arginine supplementation did not induce major changes in arginase activity thus refuting a role of arginase in the potential deleterious effects of l-arginine supplemen
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Cyprodime hydrochloride Outro grupo de trabalho analisou
2024-02-20
Outro grupo de trabalho analisou 8.503 pares de gêmeos dinamarqueses de meia‐idade (Cyprodime hydrochloride de cognição comparados com os que não sofreram qualquer intervenção, no entanto os autores consideram a diferença como um efeito de tamanho negligenciável. Na análise intrapares o gêmeo expos
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Derivatives of M that possess either an
2024-02-20
Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these MYK-461 to maintain 5-HTR antagonist properties as (+)-M100907 was demonstrated
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AZD3264 In the final set of experiments
2024-02-20
In the final set of experiments, the dependence of the reaction rate on viscosity was determined. The experimental protocol previously used to study the reaction of LOX with AA was used., Reactions of 5-LOX and AA were carried out at different relative viscosities in Tris buffer (25mM, pH 8.0) at 20
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Our co IP data show that HT
2024-02-20
Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun
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br Introduction S http www apexbt com media diy images
2024-02-20
Introduction Systemic lupus erythematosus (SLE) is a group of systemic autoimmune disorders characterized by anti-nuclear Cyclosporin H (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: ad
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PS 341 At first the APC is a kDa
2024-02-20
At first, the APC is a 310kDa protein divided into three domains such as N-terminal, central core and C-terminal domain [102], plays a major role to regulate the Wnt signaling pathway in human cancer by translating β-catenin from the PS 341 to the nucleus [103]. The SIRT1 regulates the Wnt signalin
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The importance of TARPs for
2024-02-19
The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule Niflumic acid (Chen et al., 200
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Consideration of the rate of product formation at
2024-02-19
Consideration of the rate of product formation at different substrate concentrations and estimation of Michaelis-Menten parameters gives some insight into the possible mechanisms underlying the observed decreases in enzyme activity. Estimates based on two-substrate concentrations lack precision and
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br Conflict of interest br Introduction Colorectal cancer CR
2024-02-19
Conflict of interest Introduction Colorectal cancer (CRC) is one of the major cause of tumor-related morbidity and mortality worldwide. Poor prognosis and consequences of its metastatic spread make CRC the second most common cause of cancer-related deaths in western countries [1]. Apart from o
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