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In conclusion starting from the weakly potent GSM
2021-10-08
In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Dyphylline australia led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reporte
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We have previously designed an azobenzene based
2021-10-07
We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u
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Recent research has focused on identifying key agonists and
2021-10-07
Recent research has focused on identifying key agonists and receptors mediating nutrient-induced GLP-1 and insulin secretion. The long-chain fatty 6-O-α-Maltosyl-β-cyclodextrin receptor GPR40 is the most abundant GPCR expressed in islet β cells and is also expressed on intestinal L-cells, where it
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It has been demonstrated that RA regulates
2021-10-07
It has been demonstrated that RA regulates gene rac1 inhibitor through an epigenetic mechanism during stem cell and cancer cell differentiation. In neuroblastoma cells, RA induced neural maturation through RET gene transcriptional activation by increasing H3K4me3 levels at the promoter region and d
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The stable association of Hat complexes with histones
2021-10-07
The stable association of Hat1 complexes with histones H3 and H4 raises a number of interesting issues. The first is the question of how Hat1 remains stably associated with histones H3 and H4. While the simple answer is that Hat1 remains bound to histones because of its association with histone chap
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br Conflict of interest statement
2021-10-07
Conflict of interest statement Introduction The Hedgehog (Hh) family of secreted protein signals patterns many tissues and structures during embryogenesis (Chiang et al., 1996, Dessaud et al., 2008, Ingham, 1993) and, post-embryonically, governs tissue homeostasis and regeneration by regulatin
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Furthermore we also found that both activation
2021-10-07
Furthermore, we also found that both activation of oncogenes and inactivation of tumor suppressor genes occurred in HBV oval cells, which showed opposite pattern in HBV hepatocytes. These genes might take part in neoplastic transformation of oval cells induced by HBV regarding the multipotent role o
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br Ethical approve and consent
2021-10-07
Ethical approve and consent to participate Consent for publication Availability of supporting data Competing interests Funding This work was supported by a grant from Key Program of National Natural Science Foundation of China (No. 81330089) and the Shanghai Science and Technology Fun
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Interestingly studies from Sahai and
2021-10-07
Interestingly, studies from Sahai and colleagues in cancer-associated fibroblasts have revealed that YAP is required for the acquirement of a stiff ECM in the tumor microenvironment (Calvo et al., 2013). Subsequently, this stiffening of the matrix can activate YAP, thus creating a feed-forward loop.
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T-5224 Although it is currently unknown why the longer
2021-10-07
Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the T-5224 receptor splice variant ERbeta2 identified in human and primate, but not other species (Sierens, et
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The patterns of Fig Fig emerge at the multicellular
2021-10-06
The patterns of Fig. 1, Fig. 2 emerge at the multicellular level; their dynamics can only be understood by integrating different magnitudes and feedback loops in networks incorporating the coupling between biochemical and bioelectrical signals (see Fig. 6, Fig. 8). Interestingly, this might also be
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Some but not all GSIs
2021-10-06
Some, but not all, GSIs inhibit signal peptide peptidases as well, though this has not been systemically studied [36], [41]. When considering biological activities of various GSIs this is an important and understudied caveat that could influence both biological response as well as potential toxiciti
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br Introduction The fibroblast growth factor receptor FGFR p
2021-10-04
Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, ON123300 progression, metabolism, and survival. In non–small-cell lung cancer, the most f
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br Acknowledgments br Introduction Prenyltransferase catalyz
2021-10-03
Acknowledgments Introduction Prenyltransferase catalyzes the head-to-tail condensation between isopentenyl diphosphate (IPP, 1) and an allylic prenyl diphosphate to produce several prenyl diphosphates, which are then converted into steroids, carotenoids, prenyl side-chains of quinones, and pre
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DLS only provides a Z
2021-10-03
DLS only provides a Z-average size based on spherical model, hence the size of nanorods was determined as 300 nm by DLS measurement. However, the size of length is nearly 400 nm while width is about 100 nm, which was clearly observed by transmission electron microscopy (TEM) (D). Meanwhile, the TEM
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