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Now we turn to the
2022-05-16
Now we turn to the other channel through which the risk-taking incentives provided by option compensation affect corporate debt maturity. Jensen and Meckling (1976) argue that the payoff structure of debt holders in a levered firm is concave, while that of equity holders is convex, thus, shareholder
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Although it is well documented that FAAH substrates
2022-05-16
Although it is well documented that FAAH substrates can elicit analgesic effects [for review see [47,48] and that systemic poly I:C administration induces mechanical allodynia in rats [14], to our knowledge this is the first study to demonstrate that enhancing FAAH substrate levels can modulate TLR3
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br Acknowledgments We would like to thank Coordena
2022-05-16
Acknowledgments We would like to thank Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior (CAPES) and Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq) for the grants and scholarships provide to the authors of this work. Introduction Human Immunodeficiency Virus t
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FOLE was recently approved for use in PN
2022-05-13
FOLE was recently approved for use in PN-dependent patients in the United States. However, potential adverse effects of FOLE, including bleeding risk, and effects on the immune system [8], [39], render its use in certain patient populations controversial. Identification of key downstream modulators
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In addition to gonadotropes GnRHRs have also
2022-05-13
In addition to gonadotropes, GnRHRs have also been detected on somatotropes, lactotropes, thyrotropes, melanotropes, somatolactin (SL) cells, and/or corticotropes using immunohistochemical, radioligand-binding, or mRNA expression approaches across species; including fishes, rats, and humans (La Rosa
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Introduction Glycine Fig has two pivotal functions
2022-05-13
Introduction Glycine (Fig. 1; 1) has two pivotal functions as neurotransmitter in the central nervous system (CNS). Firstly, it can act as an inhibitory neurotransmitter at inhibitory glycinergic synapses where it binds to the strychnine-sensitive glycine-A binding site on glycine receptors (GlyR)
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Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) Introd
2022-05-13
Introduction Carbohydrates are some of the most stereochemically complex biological molecules found in nature. In addition to their energetic and structural roles in living systems, their role when covalently linked to proteins is critically important in a myriad of molecular recognition processes.
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The occurrence of MDR in
2022-05-13
The occurrence of MDR in cancer patients undergoing chemotherapy can be mimicked in the laboratory by culturing cancer K02288 in the presence of chemotherapeutic drugs, thereby enforcing the evolution of acquired drug resistance. This has been described in multiple model systems including the rhabd
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Cefepime Dihydrochloride Monohydrate br WM astrocytes Grey m
2022-05-13
WM astrocytes Grey matter astrocytes express a variety of GluR types that have both physiological and pathophysiological significance [87]. Non-NMDA GluR are also expressed in WM astrocytes [40], although the functionality of these receptors has not been tested. The fibrous astrocytes that popula
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The SLC A mutations identified in both
2022-05-13
The SLC45A1 mutations identified in both families appear to be hypomorphic given that they resulted in a reduction but not abolition of intracellular glucose transport by SLC45A1 in our in vitro assay. It is tempting to speculate that recessive mutations causing a more severe dysfunction of the tran
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A key limiting factor in the semi quantitative analysis
2022-05-13
A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Triciribine of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This neces
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MRcKO mice showed a comparable degree
2022-05-13
MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G
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Post translational modifications of the GR can alter
2022-05-13
Post-translational modifications of the GR can alter the transcriptional effects of GR activation [31], and may provide a mechanism for the interactions between cell signaling pathways and GR-mediated transcriptional activity. Dex-BSA treatment reportedly increased p38 MAPK activation in CD14-positi
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Despite potent biological actions the native hormone
2022-05-13
Despite potent biological actions, the native hormone undergoes degradation by the enzyme dipeptidylpeptidase-IV (DPP-IV) [17] and is rapidly cleared from the bloodstream by renal filtration [18]. One such approach to prolong the biological half-life of GIP is through conjugation with a polyethylene
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For functional metagenomics based gene screening the DNA
2022-05-12
For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a
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