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LY3009120 br Amino acids The role of
2022-08-31
Amino acids: The role of leucine Amino LY3009120 metabolism plays a central role in brain physiology, as several amino acids serve as biosynthetic precursors for neurotransmitter synthesis [36]. In addition, the amino acids L-leucine and L-lysine may participate in ketogenesis. For these reasons
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In conclusion we demonstrated that
2022-08-29
In conclusion, we demonstrated that extrasynaptic glutamate could in situ affect the AA metabolism via brain CYPs. CYP1B1 and CYP2U1 genes in the astrocytes are the downstream genes of CREB, and the up-regulation of CYP1B1 and CYP2U1 expression by glutamate was due to the increases in phosphorylated
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Increased expression of Glut is detected in a number
2022-08-29
Increased expression of Glut1 is detected in a number of cancer types including lung [7], brain [8], bladder [9], cervical [10], colorectal [11], esophageal [12], hepatocellular [13], head and neck [14], gastric [15], ovarian [16], renal cell [17], pancreatic [18], thyroid [19] and breast [20]. Over
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kinesin 5 In spite of the similarities of caffeine s effects
2022-08-29
In spite of the similarities of caffeine's effects in L929 cells and erythrocytes, a major difference can be identified in the magnitude of inhibition (35% versus 90%). It initially seems reasonable to conclude from this finding that the reduced magnitude of caffeine inhibition in L929 cells is simp
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br Results br Discussion Using a novel viral vector for
2022-08-29
Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor Tubastatin A from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to changes in no
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Phylogenetic analysis of the secretin like hormones yields p
2022-08-29
Phylogenetic analysis of the secretin-like hormones yields poorly supported trees due to the short length of their peptide sequences (Dores et al., 1996). However, phylogenetic analyses typically show that the secretin-like peptides encoded by the proglucagon (glucagon, GLP-1 and GLP-2) and GIP Bara
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In the absence of HH ligand HH signaling is actively
2022-08-29
In the absence of HH ligand, HH signaling is actively maintained in a repressed state by the activity of the HH receptor Patched (PTCH). PTCH is a 12-transmembrane domain protein whose intracellular localization is concentrated at the exportin of the primary cilium, a single antenna-like structure
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ETV plays an important role in tumorigenesis
2022-08-29
ETV5 plays an important role in tumorigenesis and metastasis. For example, chromosomal rearrangement of ETV5 which results in increased ETV5 level is believed as a common event driving human prostate cancer (Helgeson et al., 2008; Huang and Waknitz, 2009). Ghrelin/acyl-ghrelin also plays an importan
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Emergent studies have recently shown that Sherpas living
2022-08-29
Emergent studies have recently shown that Sherpas living at high altitude have adaptations that make life at high altitude more compatible. Sherpas are known to have blood Hb concentrations about the same as lowlanders and Han populations [30]. This is different from what happens to lowlanders, Han
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Cathepsin G Inhibitor I uPAR promotes cell associated proteo
2022-08-29
uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot
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Histamine functions as a key neurotransmitter
2022-08-26
Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway
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Estradiol Cypionate FoxM a downstream target of Gli
2022-08-26
FoxM1, a downstream target of Gli, has been mainly related to Estradiol Cypionate regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression (Wo
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Importantly recent in vivo results demonstrated that combini
2022-08-26
Importantly, recent in vivo results demonstrated that combining an HDACi and a IKK inhibitor significantly reduced ovarian tumor growth compared with either inhibitor alone [26]. The slowest tumor growth in the HDACi/IKK inhibition combination group was associated with the lowest CXCL8 tumor and pla
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br Author Contributions br Acknowledgments We thank Hiroyuki
2022-08-26
Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members
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The absence of direct oxidation of
2022-08-26
The absence of direct oxidation of Fe2+ by L1 in experiments in solution would be consistent with the recognized low O2 affinity of sGC. It is known that, in atipamezole with other hemoproteins, such as globins and heme-containing oxygenases with a Fe2+-proximal histidine linkage, sGC prevents oxid
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