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While resistance to imatinib is rare in patients treated
2019-04-23
While resistance to imatinib is rare in patients treated in CML-CP, resistance does eventually develop in the majority of patients treated in the advanced phases. In a high proportion of patients who develop secondary resistance after initial responses, point mutations in the BCR-ABL kinase domain h
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purchase R115777 Perhaps counter intuitively the most strate
2019-04-23
Perhaps counter-intuitively, the most strategic tobacco control policies to reduce adolescent smoking and secondhand smoke exposure in LMICs may not be those targeting adolescents. Targeted campaigns can be expensive, and are unlikely to be as effective as the more affordable tobacco control policie
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br Signal averaged electrocardiography SAECG SAECG is a high
2019-04-23
Signal-averaged electrocardiography (SAECG) SAECG is a high-resolution electrocardiographic technique developed in the 1970s for detecting patients who are prone to SCD after MI. It is based on the theory that lethal ventricular arrhythmias leading to SCD often have a reentrant mechanism. Reentry
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En esa reuni n se acord hacer un llamamiento para
2019-04-22
En esa reunión se acordó hacer un llamamiento para sugerir acciones de cara concentration calculation anular aquella celebración. Al día siguiente, se realizó una asamblea en el Casal Catalán a la que ya acudieron un centenar de personas, convocadas de forma improvisada y movilizadas por el boca a b
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In a previous report it was speculated
2019-04-22
In a previous report, it was speculated that withdrawal syndrome after IM cessation was related to a loss of blocking tyrosine kinases, such as c-kit and platelet-derived growth factor receptor (PDGFR) [2]. The inhibition of c-kit and PDGFR by IM reduces and increases the number of osteoclasts and o
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The number of residents in London
2019-04-22
The number of residents in London who were originally from the 21 endemic countries in Central and South America was calculated from the 2011 UK National Census and was stratified by borough. We did not include undocumented migrants and individuals born to mothers from endemic Latin American countri
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pikfyve inhibitor br A few years ago my group published an
2019-04-22
A few years ago, my group published an article entitled uhuru. is the Swahili word for “freedom”. The idea was to highlight the plight of patients with end-stage kidney disease (ESKD) and the challenges and frustrations of their nephrologists in sub-Saharan Africa amidst health-care authorities t
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br Conflict of interest statement br
2019-04-22
Conflict of interest statement Acknowledgement We thank the constant support of nanomedicine research from the Ming Hsieh Institute for Research on Engineering-Medicine for Cancer. The authors certify that they have no affiliations with or involvement in any organization or entity with any fin
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Although the CHADS score is useful for evaluating the risk
2019-04-22
Although the CHADS2 score is useful for evaluating the risk of stroke in NVAF patients, about half of all NVAF patients have a score of 0 or 1 [7]. There are no clear guidelines on whether warfarin should be administered or not, to these patients because the risk of annual incidence of stroke is so
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br Conclusions br Study limitations br Conflict of interest
2019-04-22
Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum h
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Concurrent with the clinical evaluation
2019-04-22
Concurrent with the clinical evaluation of the family, the genetic findings from a molecular autopsy may help to elucidate the cause of death in the decedent, as well as provide a basis for cascade genetic testing of at-risk family members. Offering cascade genetic testing to asymptomatic relatives
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Case reports br Discussion RV perforation is
2019-04-22
Case reports Discussion RV perforation is a rare but serious complication of PPM and ICD implantation. It is diagnosed when at least the tip of a passive fixation lead or the screw of an active fixation lead passes through the myocardium and extends into the pericardial cavity [1]. This complica
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Paying now rather than forever
2019-04-22
Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set
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De acordo com algumas pesquisas os neo
2019-04-22
De acordo com algumas pesquisas os (neo) pentecostais e a rcc colaboraram de forma decisiva para o ressurgimento na liturgia cristã no país da transformação moral dos indivíduos, do ideário da família e da rígida moral sexual. No caso da Igreja católica, o avanço do projeto moral da rcc promoveu um
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br Acknowledgements br Introduction The chronic
2019-04-22
Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–
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