• br Conflict of interest statement

  2021-09-28

  

  Conflict of interest statement Acknowledgements RF is supported by Pancreatic Cancer Research Fund (grant to MF); MF is supported by Prostate Cancer UK (PG12-23 and PG13-029). Background Lysophosphatidylinositol Molecular species and the biosynthesis of phosphatidylinositol, the precu

• Ca independent release of L C glutamate and GABA that

  2021-09-28

  

  Ca2+-independent release of L-[14C]glutamate and [3Н]GABA that occurs via transporters working in the reverse mode also insignificantly increased in vitamin D3 deficiency despite decreased GAT-3 and EAAC-1 BHQ and neurotransmitter uptake efficacy Fig. 3, Fig. 6 A). However, the upward tendency in G

• Olanzapine has been reported to attenuate insulin secretion

  2021-09-28

  

  Olanzapine has been reported to attenuate insulin secretion, cause insulin resistance (Chintoh et al., 2008) and reduce whole body carbohydrate oxidation (Klingerman et al., 2014). However, a blunting of these effects in Gcgr−/− mice would not appear to explain the protection against olanzapine-indu

• TXNIP interacts with various proteins including NLRP

  2021-09-27

  

  TXNIP interacts with various proteins, including NLRP3 (Yoshihara et al., 2014, Zhou et al., 2010). Emerging evidence suggests that TXNIP plays a role in ER stress-mediated cell death and in the NLRP3 inflammasome activation step (Abderrazak et al., 2015, Lerner et al., 2012, Oslowski et al., 2012,

• In addition to indoles two

  2021-09-27

  

  In addition to indoles –, two additional structural variants were synthesized to explore the synthetic flexibility and structure–activity relationships of this system. The first of these was the homologation of the acetic NSC23766 side chain to prepare compound (). The extension of the chain was e

• The H R couples to G i

  2021-09-27

  

  The H3R couples to Gαi/o proteins, and hence its stimulation leads to inhibition of adenyalate cyclases, diminishing the level of cyclic AMP (cAMP) with the subsequent reduction in downstream signaling pathways such as protein kinase A (PKA) activation and cAMP-responsive element binding protein (CR

• It is an exciting time for translational histamine research

  2021-09-27

  

  It is an exciting time for translational histamine research, since preclinical studies show potential value for histamine receptor ligands. As reviewed above, there are several concerns for future studies of histamine and its role in the CNS. 1) Because of the availability of HDC-Cre mice (Williams

• br Hedgehog in chronic liver disease The liver responds to

  2021-09-27

  

  Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li

• On the basis of the structure

  2021-09-27

  

  On the basis of the structure of the Rab35/ACAP2 complex, the authors identified Thr76 in switch II of Rab35 as one key specificity determinant (Lin et al., 2019). The crystal structure shows that the hydroxyl group of Thr76 forms a ubiquitin activating enzyme with Asp756 in ACAP2, while the methyl

• EW-7197 ICH induced striatal lesion produced a reduction of

  2021-09-27

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino EW-7197 transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (R

• The previous study demonstrated that

  2021-09-27

  

  The previous study demonstrated that the main CYP isoforms present in the human choline alfoscerate synthesis included CYP46A1, 2J2, 2U1, 1B1, 2E1 and 2D6 (Dutheil et al., 2009b, 2010). CYP1B1 and CYP2U1 were found in the mitochondrial and microsomal fractions of astrocytes in the human frontal lobe

• In glioma or glial derived

  2021-09-27

  

  In glioma, or glial-derived primary Cisplatin tumors, as in other cancers, glutathione is an important survival mechanism. Glioma cells are dependent upon SXC-mediated cystine uptake for viability, as they require intracellular cystine/cysteine for GSH synthesis (Ogunrinu and Sontheimer, 2010, Sont

• In patients with type diabetes glucagon receptor antagonism

  2021-09-26

  

  In patients with type 2 diabetes glucagon receptor antagonism led lowered fasting glucose however not postprandial glucose levels [9], which may reflect that glucagon may not be of particular importance for the diabetic hyperglycemia upon a meal. Current glucagon receptor antagonists have however be

• Here we examined whether complete

  2021-09-26

  

  Here, we examined whether complete ablation of GIP production could reduce weight gain in the absence of the adipocyte hormone leptin, a condition that results in extreme hyperphagia, obesity, hyperinsulinemia, and insulin resistance, in both mice [24] and humans [25]. We found that Lepob/ob mice be

• Earlier we have showed that tumor

  2021-09-26

  

  Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is

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