• br Conclusion and future perspectives

  2022-03-31

  

  Conclusion and future perspectives The nicotinic BX-912 receptor GPR109A and its close relatives GPR109B and GPR81 are primarily expressed in adipocytes and are coupled to Gi-type G proteins. Recently, the ketone body β-hydroxy-butyrate, the β-oxidation intermediate 3-hydroxy octanoic acid and l

• br Glycoengineering br The Omics perspective

  2022-03-31

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO Propidium iodide for improved glycoprotein produ

• A further generally applicable approach

  2022-03-31

  

  A further generally applicable approach for the synthesis of N-linked glycopeptides involves the convergent Lansbury aspartylation of glycosylamines. Here, the detrimental formation of aspartimides during the activation of the side chain aspartate can be prevented through the use of Ser/Thr pseudopr

• Histamine functions as a key neurotransmitter in multiple

  2022-03-31

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, Cytarabine mg is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pat

• In the present study co

  2022-03-31

  

  In the present study, co-administration of TM (AT1 receptor blocker) and PD (AT2 receptor blocker) were made in ischemic mice to explore the significance of AT2 receptors in cerebral ischemia while blocking central AT1 receptors. Also to prove that AT2 receptors should be free after ischemic injury

• There are two ways to transport FFAs into

  2022-03-31

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty HG-9-91-01 transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible

• br Experimental br Acknowledgments This project was generous

  2022-03-31

  

  Experimental Acknowledgments This project was generously supported by Grünenthal GmbH and IECB. We also thank the staff members of the technical platform of IECB and Grünenthal GmbH for their availability and their skills. Introduction Glucocorticoids (GCs) are essential steroid hormones t

• Besides its established insulinotropic actions GIP has been

  2022-03-30

  

  Besides its established insulinotropic actions, GIP has been shown to possess other direct beneficial effects on the beta cell, including stimulation of growth, differentiation, proliferation and survival.21, 22, 23 It has also been shown to stimulate proinsulin gene transcription and translation. M

• A relatively independent review of

  2022-03-30

  

  A relatively independent review of the history of the discovery of GABA (and L-glutamate) as neurotransmitters in the CNS can be found in ‘When and why amino acids?’ in the in 2010 by Kresimir Krnjevic , who spent a post-doc in Canberra in 1956–1958. Introduction The insect RDL GABA receptor is

• Compounds were tested for GPR activity in a

  2022-03-30

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO BADGE transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activity relat

• br G protein coupled receptor GPR also

  2022-03-30

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty (S)-(+)-Dimethindene maleate receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented tha

• Carmofur As a part of our continuing

  2022-03-30

  

  As a part of our continuing efforts towards discovery of new class of compounds against different therapeutic areas and based on the literature reports, we designed a dual pharmacophore which possess a long aliphatic chain of free fatty acids and a phenyl propanoid part of known GPR40 agonists. Here

• br Introduction For decades regulated apoptosis and unregula

  2022-03-30

  

  Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma

• br Materials and methods br Results and discussion In

  2022-03-30

  

  Materials and methods Results and discussion In order to identify genes required for photoautotrophic growth, we screened a random insertion mutant library of Synechocystis 6803 and obtained many mutants with impaired photoautotrophic growth. About 6000 random insertion colonies of the mutant

• 2750 Most studies to date have focused on the

  2022-03-30

  

  Most studies to date have focused on the physiological functions of FPS in plants. As mentioned above, numerous factors affect FPS expression and FPS function. However, FPS enzymatic assays require radiolabeled substrate and thus detailed enzymatic characterizations of FPS, including substrate spec

15342 records 403/1023 page Previous Next First page 上5页 401402403404405 下5页 Last page