• Furthermore a direct thiol protective role

  2022-04-22

  

  Furthermore, a direct thiol protective role of S-nitrosylation has been reported in animals [66]. Here, formation of higher order irreversible oxidative modifications, such as sulfinic and sulfonic acids were prevented by S-nitrosylation. All these observations underline the important role of ROS in

• Considering that loss of LAG expression results in increased

  2022-04-22

  

  Considering that loss of LAG-3 900 80 results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed, Lag3-deficie

• The amyloid precursor protein APP is

  2022-04-22

  

  The amyloid precursor protein (APP) is a membrane protein thought to be involved in plasticity, synapse formation and repair, and export of metal ions [68]. The APP present in the brain can be cleaved by three different secretases [73], [74]. Cleavage of APP first by alpha secretase and then gamma-s

• Studies have shown that coexpression of

  2022-04-21

  

  Studies have shown that coexpression of the HAC1 gene in P. pastoris improved the Levodopa synthesis level of foreign proteins [24,25]. By coexpression with PDI and Ero1, the expression level of the coexpressed strains was increased by 60% [26]. In our study, the α-galactosidase gene was coexpressed

• br Acknowledgements This work was supported under the Nation

  2022-04-21

  

  Acknowledgements This work was supported under the National Natural Science Foundation of China (Grant numbers 31200576, 21472197, 21675162), Beijing Natural Science Foundation (Grant No. 7182189), and Project supported by the Joint Funds of the National Natural Science Foundation of China (Grant

• Dihydroeponemycin br FPRs regulate anti microbial responses

  2022-04-21

  

  FPRs regulate anti-microbial responses The classic evidence supporting FPR as an anti-microbial receptor is that bacteria are the major biological source of chemotactic formyl peptides, fMLF binds to FPR and fMLF activates chemotactic and anti-microbial responses in neutrophils 2., 3.. Recently,

• br Material and methods br Results br Discussion

  2022-04-21

  

  Material and methods Results Discussion In the present study, we attempted to unravel the mechanism underlying the statin-mediated inhibition of FGFR3 signaling in chondrocytes, reported earlier by Yamashita and colleagues. We evaluated the role of statins in four different experimental sys

• Reducing the molecular weight According to

  2022-04-21

  

  Reducing the molecular weight: According to a thorough analysis of a large, structurally diverse Caco-2 permeability dataset using a variety of statistical techniques by AstraZeneca researchers, logD and molecular weight are suggested the most important factors in determining the permeability of dru

• Despite a large amount of uptake for both

  2022-04-21

  

  Despite a large amount of uptake for both nanoparticles, only after transport across intestinal epithelia do the nanoparticles really contribute to improving absorption. Though the transport of nanorods across monolayer was a little bit more than nanospheres, the total transport was less than 2% (A1

• While histone modifications can alter inter nucleosomal

  2022-04-21

  

  While histone modifications can alter inter-nucleosomal interactions that govern the compaction state of a chromatin fiber (Francis et al., 2004, Kalashnikova et al., 2013, Lu et al., 2008), the potential impact of histone modifications on higher-order chromosome organization beyond chromatin-fiber 

• Human epidermal growth factor receptor HER neu also known as

  2022-04-20

  

  Human epidermal growth factor receptor 2 (HER2/neu, also known as CerbB-2, or ERBB-2) is a proto-oncogene located on chromosome 17q21, which encodes a transmembrane protein with tyrosine kinase activity, and belongs to the HER receptor family (EGFR, named also HER1, HER3, and HER4) [6]. HER2 is invo

• VU590 hydrochloride br GSNOR regulates SA synthesis and SA

  2022-04-20

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic VU590 hydrochloride (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal r

• Studies utilising GPR mice however report different

  2022-04-20

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• br Materials and methods br Results br Discussion According

  2022-04-20

  

  Materials and methods Results Discussion According to the literature, zaprinast is a high-affinity agonist of GPR35 (Berlinguer-Palmini et al., 2013, Divorty et al., 2015, Taniguchi et al., 2006, Zhao et al., 2010). GPR35 oxytocin receptor has been identified within discrete regions of the

• Biochemical assays have provided evidence that prolonged exp

  2022-04-20

  

  Biochemical assays have provided evidence that prolonged exposure to GPR35 agonists can induce GPR35 internalization [2], [4], [11], [13]. Our finding that neuronal excitability decreased regardless of whether the slices were superfused for a few minutes or incubated for a few hours with GPR35 agoni

15471 records 400/1032 page Previous Next First page 上5页 396397398399400 下5页 Last page